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Signs You May Benefit From Testosterone Therapy As men age, hormone levels naturally decline. Starting around age 30, testosterone slowly decreases—and for many men, that decline intensifies with time. This can lead to common symptoms of andropause, such as: Low energy and fatigue Decreased libido or sexual performance Loss of muscle mass Reduced motivation or drive Mood changes or irritability Loss of interest in hobbies or activities These changes can happen gradually, unti